منابع مشابه
Fibroblast growth factor rescues brain endothelial cells lacking presenilin 1 from apoptotic cell death following serum starvation
Presenilin 1 (Psen1) is important for vascular brain development and is known to influence cellular stress responses. To understand the role of Psen1 in endothelial stress responses, we investigated the effects of serum withdrawal on wild type (wt) and Psen1-/- embryonic brain endothelial cells. Serum starvation induced apoptosis in Psen1-/- cells but did not affect wt cells. PI3K/AKT signaling...
متن کاملSestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death
Sestrin2 is a member of a family of stress responsive proteins, which controls cell viability via antioxidant activity and regulation of the mammalian target of rapamycin protein kinase (mTOR). Sestrin2 is induced by different stress insults, which diminish ATP production and induce energetic stress in the cells. Glucose is a critical substrate for ATP production utilized via glycolysis and mit...
متن کاملEliminating the death penalty from drug crimes: requirements and Prohibitions
The Ideaof the capability of the death penalty to deal with drug-related crimes is, in essence, a guarantor of the goal of safeguarding human capital and social values. Certainly, Use of the death penalty can be accepted in response to some of the narcotics crimes. But there are many other crimes that follow the death penalty, but they can be categorically opposed and unsuccessful. Execution is...
متن کاملDeath from Hemophagocytic Lymphohistiocytosis Syndrome Due to Generalized Hemorrhage
Hemophagocytic lymphohistiocytosis (HLH) is the result of excessive cytokine release, leading to over-response by immune cells, such as macrophages and T lymphocytes. Here, we report a lethal case of HLH with a complete clinical course. The patient was a 45-year-old man with fever and chills since two months ago plus splenomegaly, hepatomegaly, and pancytopenia. The Anti-HBc IgM was positive, b...
متن کاملArginine starvation-associated atypical cellular death involves mitochondrial dysfunction, nuclear DNA leakage, and chromatin autophagy.
Autophagy is the principal catabolic prosurvival pathway during nutritional starvation. However, excessive autophagy could be cytotoxic, contributing to cell death, but its mechanism remains elusive. Arginine starvation has emerged as a potential therapy for several types of cancers, owing to their tumor-selective deficiency of the arginine metabolism. We demonstrated here that arginine depleti...
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ژورنال
عنوان ژورنال: The Dublin Journal of Medical Science
سال: 1887
ISSN: 0790-231X
DOI: 10.1007/bf02969890